Evaluation of Multiple Imputation Methods for Missing Diary Data for Statistical Analysis in Dry Eye Studies

ARVO Annual Meeting, May 2018

Missing data is a common occurrence when collecting patient responses via patient symptom diaries. Many methodologies exist for imputing missing data and are used to estimate statistical outcomes that would have been achieved had no missing data occurred. Among the many imputation methodologies are varying multiple imputation techniques which are becoming more prevalent in clinical research. We performed a simulation study to compare statistical outcomes based on three MI methods to handle missing data versus statistical outcomes based on single imputation methods as previously reported by Hsu et al. at the 2013 ARVO conference.